Innatrix is an early-stage agricultural biotechnology company developing sustainable biological and chemical products to control untreatable crop diseases, pests and weeds. We have received a U.S. patent to protect our key protein evolution technology. We are funded by a NSF SBIR grant, and found our market fit after going through the rigorous NSF I-Corps program.
We have received a patent for our continuous laboratory evolution platform. The platform enables Innatrix researchers to rapidly produce high-affinity, high-specificity protein ligands to target proteins of interest from pathogens/pests. The developed protein ligands will exert their effects by binding to cellular target proteins. If a target protein and a ligand are a good “fit,” with matching nooks and crannies that allow them to bind together tightly, the process will cause the target proteins to malfunction, so that the pathogens/pests are controlled.
Compared to the widely used phage display technology, our platform has the following advantages:
|Items/Techniques||Phage display||Innatrix platform|
|Product size||Only small peptides||Small peptides to big proteins|
|Capacity/speed||1-2 generations/day||Up to 38 generations/day|
|Human effort||Labor intensive||Highly automated|
|Selection occurs||Outside of cells||Intra-cellular|
InnaLB™ — to provide potato late blight control;
InnaNema™ — to provide soybean cyst nematode control;
InnaHLB™ — to provide citrus greening control.
|Gene discovery||Target protein
(potato late blight)
(soybean cyst nematode)
Innatrix has also invented a proprietary apparatus named the EvoStat™. It is an automated platform for protein engineering via continuous laboratory evolution or other approaches such as phage display or SIP-phage display. The EvoStat™ provides advanced control, reporting, recording, simulation, and remote access. Infra-red and image processing-based monitoring provides control of temperature, mixing, turbidity, medium supply, culture volumes and flow rates. All EvoStat™ measurements are logged during experimental runs and are available for plotting and analysis. Specific plots such as temperature, culture volumes, and flow rates are directly available through its browser interface.
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