Evolutionary Methods |
Revolutionary Products |
Evolutionary Methods |
Revolutionary Products |
Innatrix is an early-stage agricultural biotechnology company developing sustainable biological and chemical products to control untreatable crop diseases, pests and weeds. We have received a U.S. patent to protect our key protein evolution technology. We are funded by a NSF SBIR grant, and found our market fit after going through the rigorous NSF I-Corps program.
We have received a patent for our continuous laboratory evolution platform. The platform enables Innatrix researchers to rapidly produce high-affinity, high-specificity protein ligands to target proteins of interest from pathogens/pests. The developed protein ligands will exert their effects by binding to cellular target proteins. If a target protein and a ligand are a good “fit,” with matching nooks and crannies that allow them to bind together tightly, the process will cause the target proteins to malfunction, so that the pathogens/pests are controlled.
Compared to the widely used phage display technology, our platform has the following advantages:
| Items/Techniques | Phage display | Innatrix platform |
|---|---|---|
| Time created | 1985 | 2019 |
| Product size | Only small peptides | Small peptides to big proteins |
| Capacity/speed | 1-2 generations/day | Up to 38 generations/day |
| Human effort | Labor intensive | Highly automated |
| Application difficulty | Hard | Easy |
| Selection occurs | Outside of cells | Intra-cellular |
InnaLB™ — to provide potato late blight control;
InnaNema™ — to provide soybean cyst nematode control;
InnaHLB™ — to provide citrus greening control.
| Indication | Product Maturity | Market | |||
|---|---|---|---|---|---|
| Gene discovery | Target protein identification |
Identifying protein ligands |
Efficacy test | ||
| InnaLB™ (potato late blight) |
✔ | ✔ | ✔ | $6.7 billion | |
| InnaNema™ (soybean cyst nematode) |
✔ | ✔ | >$1 billion | ||
| InnaHLB™ (citrus greening) |
✔ | ✔ | $multi-billion | ||
Innatrix has also invented a proprietary apparatus named the EvoStat™. It is an automated platform for protein engineering via continuous laboratory evolution or other approaches such as phage display or SIP-phage display. The EvoStat™ provides advanced control, reporting, recording, simulation, and remote access. Infra-red and image processing-based monitoring provides control of temperature, mixing, turbidity, medium supply, culture volumes and flow rates. All EvoStat™ measurements are logged during experimental runs and are available for plotting and analysis. Specific plots such as temperature, culture volumes, and flow rates are directly available through its browser interface.
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Innatrix Inc.
104 T.W. Alexander Drive
Building 20, Suite 2020
Research Triangle Park,
North Carolina
27709
·····
Jiarui Li
email
Copyright © 2021 Innatrix Inc. All rights reserved.
104 T.W. Alexander Drive ·
Bldg. 20, Suite 2020 ·
Research Triangle Park · North Carolina · 27709
Jiarui Li
email