Innatrix is an early-stage agricultural biotechnology company developing sustainable biological and chemical products to control untreatable crop diseases, pests and weeds. We have received a U.S. patent to protect our key protein evolution technology. We are funded by a NSF SBIR grant, and found our market fit after going through the rigorous NSF I-Corps program.


We have received a patent for our continuous laboratory evolution platform. The platform enables Innatrix researchers to rapidly produce high-affinity, high-specificity protein ligands to target proteins of interest from pathogens/pests. The developed protein ligands will exert their effects by binding to cellular target proteins. If a target protein and a ligand are a good “fit,” with matching nooks and crannies that allow them to bind together tightly, the process will cause the target proteins to malfunction, so that the pathogens/pests are controlled.

Compared to the widely used phage display technology, our platform has the following advantages:

Items/Techniques Phage display Innatrix platform
Time created 1985 2019
Product size Only small peptides Small peptides to big proteins
Capacity/speed 1-2 generations/day Up to 38 generations/day
Human effort Labor intensive Highly automated
Application difficulty Hard Easy
Selection occurs Outside of cells Intra-cellular


     InnaLB™ — to provide potato late blight control;

     InnaNema™ — to provide soybean cyst nematode control;

     InnaHLB™ — to provide citrus greening control.

Indication Product Maturity Market
Gene discovery Target protein
protein ligands
Efficacy test
(potato late blight)
$6.7 billion
(soybean cyst nematode)
>$1 billion
(citrus greening)


Innatrix has also invented a proprietary apparatus named the EvoStat™. It is an automated platform for protein engineering via continuous laboratory evolution or other approaches such as phage display or SIP-phage display. The EvoStat™ provides advanced control, reporting, recording, simulation, and remote access. Infra-red and image processing-based monitoring provides control of temperature, mixing, turbidity, medium supply, culture volumes and flow rates. All EvoStat™ measurements are logged during experimental runs and are available for plotting and analysis. Specific plots such as temperature, culture volumes, and flow rates are directly available through its browser interface.

Innatrix Inc.
104 T.W. Alexander Drive
Building 20, Suite 2020
Research Triangle Park,
North Carolina


Jiarui Li